InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad51ap1

Summary

InnateDB Protein

IDBP-256483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad51ap1

Protein Name

RAD51 associated protein 1

Synonyms

2510006L10Rik; RAB22;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107841

InnateDB Gene

IDBG-190440 (Rad51ap1)

Protein Structure

UniProt Annotation

Function

May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9192668}. Note=Colocalizes with RAD51 to multiple nuclear foci.

Disease Associations

Tissue Specificity

Most abundantly expressed in testis. Also expressed in spleen, thymus and bone marrow. Not detected in heart, kidney or liver. {ECO:0000269PubMed:9192668}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0071479	cellular response to ionizing radiation