Mus musculus Protein: Sfmbt1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-256534.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Sfmbt1 | ||||||||||||||
Protein Name | Scm-like with four mbt domains 1 | ||||||||||||||
Synonyms | 4930442N21Rik; 9330180L21Rik; AA536974; Sfmbt; Smr; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000107799 | ||||||||||||||
InnateDB Gene | IDBG-143087 (Sfmbt1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. {ECO:0000269PubMed:23349461}. | ||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Highly expressed in the testis, low expression is detected in brain, kidney, heart and lung. Highly expressed in germ cells, where it associates with the synaptic regions of meiotic chromosomes in pachytene stage spermatocytes. {ECO:0000269PubMed:10806358, ECO:0000269PubMed:23592795}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:1859609 | ||||||||||||||
InterPro |
IPR001660
Sterile alpha motif domain IPR004092 Mbt repeat IPR011510 Sterile alpha motif, type 2 IPR013761 Sterile alpha motif/pointed domain IPR021129 Sterile alpha motif, type 1 IPR021987 Protein of unknown function DUF3588 |
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PFAM |
PF02820
PF07647 PF00536 PF12140 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00454
SM00561 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9JMD1 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9JMD1 | ||||||||||||||
TrEMBL | E9Q354 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 54650 | ||||||||||||||
UniGene | Mm.294662 | ||||||||||||||
RefSeq | |||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Sfmbt1 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS26897 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AB032165 AC154436 BC036972 BC066188 | ||||||||||||||
GenPept | AAH36972 AAH66188 BAA96305 | ||||||||||||||