InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msl3

Summary

InnateDB Protein

IDBP-256638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msl3

Protein Name

male-specific lethal 3 homolog (Drosophila)

Synonyms

AU018931; Msl31; Msl3l1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107765

InnateDB Gene

IDBG-185721 (Msl3)

Protein Structure

UniProt Annotation

Function

May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00972}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0035064	methylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043984	histone H4-K16 acetylation

Cellular Component

GO:0072487

MSL complex

Protein Structure and Domains

PDB ID

MGI:1341851

InterPro

IPR016197 Chromo domain-like
IPR026541 MRG domain

PFAM

PF05712

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WVG9

PhosphoSite

PhosphoSite-Q9WVG9

TrEMBL

UniProt Splice Variant

Entrez Gene

17692

UniGene

Mm.490444

RefSeq

NP_034962

MGI ID

MGI Symbol

Msl3

OMIM

CCDS

CCDS41211

HPRD

IMGT

EMBL

AF117066 AL671489 BC010226

GenPept

AAD38500 AAH10226 CAM45888 CAM45889