InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cit

Summary

InnateDB Protein

IDBP-256877.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Cit

Protein Name

citron

Synonyms

C030025P15Rik; Cit-k; CRIK; CRIK-SK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107639

InnateDB Gene

IDBG-194406 (Cit)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000910	cytokinesis
GO:0006468	protein phosphorylation
GO:0007030	Golgi organization
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0008064	regulation of actin polymerization or depolymerization
GO:0016358	dendrite development
GO:0035556	intracellular signal transduction
GO:0045665	negative regulation of neuron differentiation
GO:0050774	negative regulation of dendrite morphogenesis
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005773	vacuole
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0031985	Golgi cisterna
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:105313

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011072 HR1 rho-binding repeat
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM