InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kazald1

Summary

InnateDB Protein

IDBP-257037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kazald1

Protein Name

Kazal-type serine peptidase inhibitor domain 1

Synonyms

AI842353; Bono1; IGFBP-rP10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107579

InnateDB Gene

IDBG-170622 (Kazald1)

Protein Structure

UniProt Annotation

Function

Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly. {ECO:0000269PubMed:15555553, ECO:0000269PubMed:18757743}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:18757743}.

Disease Associations

Tissue Specificity

Highly expressed in the spleen. Moderately expressed in the skin, lung and urinary bladder. Weakly expressed in the brain, tongue, esophagus, stomach, large intestine, liver and bone. Expressed in osteoblastic cells during bone regeneration. Expressed in secretory osteoblasts in the tooth. {ECO:0000269PubMed:15261838, ECO:0000269PubMed:15555553}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001503	ossification
GO:0001558	regulation of cell growth
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576	extracellular region
GO:0005614	interstitial matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:2147606

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR002350 Kazal domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00219
PF00050
PF07648
PF07679
PF00047

PRINTS

PIRSF

PIRSF018239

SMART

SM00121
SM00280
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt