Version 5.4
Mus musculus Protein: Mmrn2
Summary
InnateDB Protein IDBP-257133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mmrn2
Protein Name multimerin 2
Synonyms AA986839; Emilin3; EndoGlyx-1; ENDOGLYX1;
Species Mus musculus
Ensembl Protein ENSMUSP00000107539
InnateDB Gene IDBG-149603 (Mmrn2)
Protein Structure
UniProt Annotation
Function Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250UniProtKB:Q9H8L6}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2385618
InterPro IPR001073 Complement C1q protein
IPR008983 Tumour necrosis factor-like domain
IPR011489 EMI domain
PFAM PF00386
PF07546
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H6E2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 105450
UniGene Mm.272673
RefSeq NP_694767
MGI ID
MGI Symbol Mmrn2
OMIM
CCDS CCDS36876
HPRD
IMGT
EMBL AK078470 BC034871 BC145845 CH466573
GenPept AAH34871 AAI45846 BAC37291 EDL24879

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca