Version 5.4
Mus musculus Protein: Arhgdib
Summary
InnateDB Protein IDBP-257172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgdib
Protein Name Rho, GDP dissociation inhibitor (GDI) beta
Synonyms D4; Gdid4; Ly-GDI;
Species Mus musculus
Ensembl Protein ENSMUSP00000107523
InnateDB Gene IDBG-195168 (Arhgdib)
Protein Structure
UniProt Annotation
Function Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Preferentially expressed in hematopoietic cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:101940
InterPro IPR000406 RHO protein GDP dissociation inhibitor
IPR014756 Immunoglobulin E-set
PFAM PF02115
PRINTS PR00492
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61599
PhosphoSite PhosphoSite-Q61599
TrEMBL D3YWL7
UniProt Splice Variant
Entrez Gene 11857
UniGene Mm.486330
RefSeq XP_006505465
MGI ID
MGI Symbol Arhgdib
OMIM
CCDS CCDS20661
HPRD
IMGT
EMBL AC125341 AK002516 AK169733 BC031763 L07918
GenPept AAA61613 AAH31763 BAB22155 BAE41335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca