InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcf7l2

Summary

InnateDB Protein

IDBP-257650.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf7l2

Protein Name

transcription factor 7-like 2, T-cell specific, HMG-box

Synonyms

mTcf-4B; mTcf-4E; Tcf-4; Tcf4; TCF4B; TCF4E;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107279

InnateDB Gene

IDBG-177837 (Tcf7l2)

Protein Structure

UniProt Annotation

Function

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000250, ECO:0000269PubMed:21856776, ECO:0000269PubMed:9697701}.

Subcellular Localization

Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies (By similarity). {ECO:0000250}.

Disease Associations

Note=Constitutive activation and subsequent transactivation of target genes may lead to the maintenance of stem-cell characteristics (cycling and longevity) in cells that should normally undergo terminal differentiation and constitute the primary transforming event in colorectal cancer (CRC).

Tissue Specificity

Detected in adult brain and liver, and at lower levels in intestine, with a clear increase from the distal colon to the duodenum. Detected at low levels in heart, lung, kidney, pituitary and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0005977	glycogen metabolic process
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0009791	post-embryonic development
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0014003	oligodendrocyte development
GO:0016055	Wnt signaling pathway
GO:0021915	neural tube development
GO:0021983	pituitary gland development
GO:0030282	bone mineralization
GO:0030514	negative regulation of BMP signaling pathway
GO:0030538	embryonic genitalia morphogenesis
GO:0031641	regulation of myelination
GO:0032024	positive regulation of insulin secretion
GO:0032252	secretory granule localization
GO:0035019	somatic stem cell maintenance
GO:0035264	multicellular organism growth
GO:0035411	catenin import into nucleus
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0043588	skin development
GO:0045599	negative regulation of fat cell differentiation
GO:0045722	positive regulation of gluconeogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046621	negative regulation of organ growth
GO:0046889	positive regulation of lipid biosynthetic process
GO:0048557	embryonic digestive tract morphogenesis
GO:0048619	embryonic hindgut morphogenesis
GO:0048625	myoblast fate commitment
GO:0048641	regulation of skeletal muscle tissue development
GO:0048713	regulation of oligodendrocyte differentiation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0060070	canonical Wnt signaling pathway
GO:0060325	face morphogenesis
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:1901142	insulin metabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway