InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF4A1

Summary

InnateDB Protein

IDBP-25781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4A1

Protein Name

eukaryotic translation initiation factor 4A1

Synonyms

DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I;

Species

Homo sapiens

Ensembl Protein

ENSP00000293831

InnateDB Gene

IDBG-25777 (EIF4A1)

Protein Structure

UniProt Annotation

Function

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269PubMed:19153607, ECO:0000269PubMed:19204291}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	99 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0003676	nucleic acid binding
GO:0003725	double-stranded RNA binding
GO:0003729	mRNA binding
GO:0003743	translation initiation factor activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006200	ATP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0031100	organ regeneration
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0016281	eukaryotic translation initiation factor 4F complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P60842