InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adamts4

Summary

InnateDB Protein

IDBP-258393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts4

Protein Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106947

InnateDB Gene

IDBG-204274 (Adamts4)

Protein Structure

UniProt Annotation

Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu--Ala-393' site (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0042742	defense response to bacterium

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1339949

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
IPR010294 ADAM-TS Spacer 1
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF08516
PF05986

PRINTS

PR01857

PIRSF

SMART

SM00209
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt