Version 5.4
Mus musculus Protein: Mboat2
Summary
InnateDB Protein IDBP-259178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mboat2
Protein Name membrane bound O-acyltransferase domain containing 2
Synonyms 2810049G06Rik; AU022889; AW547221; LPCAT4; Moact2; Oact2;
Species Mus musculus
Ensembl Protein ENSMUSP00000106567
InnateDB Gene IDBG-131242 (Mboat2)
Protein Structure
UniProt Annotation
Function Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18287005}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269PubMed:18287005}.
Disease Associations
Tissue Specificity Highly expressed in epididymis, brain, testis, and ovary. {ECO:0000269PubMed:18287005}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
Biological Process
GO:0008150 biological_process
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914466
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R3I2
PhosphoSite PhosphoSite-Q8R3I2
TrEMBL
UniProt Splice Variant
Entrez Gene 67216
UniGene
RefSeq NP_080313
MGI ID
MGI Symbol Mboat2
OMIM
CCDS CCDS25845
HPRD
IMGT
EMBL AB297383 AB305046 AK012931 AK031824 AK033106 AK034873 AK076045 BC025020
GenPept AAH25020 BAB28556 BAC27567 BAC28154 BAC28863 BAC36144 BAF93902 BAG12122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca