Mus musculus Protein: Cd34
InnateDB Protein IDBP-259447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd34
Protein Name CD34 antigen
Synonyms AU040960;
Species Mus musculus
Ensembl Protein ENSMUSP00000106439
InnateDB Gene IDBG-209317 (Cd34)
Protein Structure
UniProt Annotation
Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed in hematopoietic progenitor cell lines, brain and testis, and moderately in the thymus, spleen, and bone marrow, but not in adult liver.
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008134 transcription factor binding
GO:0030246 carbohydrate binding
GO:0043199 sulfate binding
Biological Process
GO:0001894 tissue homeostasis
GO:0001935 endothelial cell proliferation
GO:0003094 glomerular filtration
GO:0003158 endothelium development
GO:0006536 glutamate metabolic process
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0008283 cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016337 single organismal cell-cell adhesion
GO:0030195 negative regulation of blood coagulation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0035759 mesangial cell-matrix adhesion
GO:0038001 paracrine signaling
GO:0042482 positive regulation of odontogenesis
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050900 leukocyte migration
GO:0060290 transdifferentiation
GO:0060547 negative regulation of necrotic cell death
GO:0061042 vascular wound healing
GO:0071425 hematopoietic stem cell proliferation
GO:0071636 positive regulation of transforming growth factor beta production
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0071971 extracellular vesicular exosome assembly
GO:0072011 glomerular endothelium development
GO:0072254 metanephric glomerular mesangial cell differentiation
GO:1900035 negative regulation of cellular response to heat
GO:1900038 negative regulation of cellular response to hypoxia
GO:1900041 negative regulation of interleukin-2 secretion
GO:1900168 positive regulation of glial cell line-derived neurotrophic factor secretion
GO:1901215 negative regulation of neuron death
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0036053 glomerular endothelium fenestra
GO:0045171 intercellular bridge
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID MGI:88329
InterPro IPR008083 CD34 antigen
IPR013836 CD34/Podocalyxin
PFAM PF06365
Post-translational Modifications
SwissProt Q64314
PhosphoSite PhosphoSite-Q64314
UniProt Splice Variant
Entrez Gene 12490
UniGene Mm.470860
RefSeq NP_001104529
MGI Symbol Cd34
EMBL AK044121 BC006607 S69293 S69295 S69299 S69301 S69302
GenPept AAB19246 AAB22108 AAB22109 AAH06607 BAC31787