InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PXDN

Summary

InnateDB Protein

IDBP-25973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PXDN

Protein Name

peroxidasin homolog (Drosophila)

Synonyms

COPOA; D2S448; D2S448E; MG50; PRG2; PXN; VPO;

Species

Homo sapiens

Ensembl Protein

ENSP00000252804

InnateDB Gene

IDBG-25971 (PXDN)

Protein Structure

UniProt Annotation

Function

Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. {ECO:0000269PubMed:18929642, ECO:0000269PubMed:19590037}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:19590037, ECO:0000269Ref.8}. Note=Enriched in the peritubular space of fibrotic kidneys.

Disease Associations

Tissue Specificity

Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis. {ECO:0000269PubMed:10441517, ECO:0000269PubMed:11103812, ECO:0000269PubMed:18929642, ECO:0000269PubMed:19590037}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005152	interleukin-1 receptor antagonist activity
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006955	immune response
GO:0006979	response to oxidative stress
GO:0030198	extracellular matrix organization
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001007 von Willebrand factor, type C
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR010255 Haem peroxidase
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR019791 Haem peroxidase, animal

PFAM