InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esr2

Summary

InnateDB Protein

IDBP-260313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esr2

Protein Name

estrogen receptor 2 (beta)

Synonyms

ER[b]; ERbeta; Estrb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106051

InnateDB Gene

IDBG-150083 (Esr2)

Protein Structure

UniProt Annotation

Function

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis. {ECO:0000269PubMed:9607809}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030284	estrogen receptor activity
GO:0034056	estrogen response element binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001541	ovarian follicle development
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008628	hormone-mediated apoptotic signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0043401	steroid hormone mediated signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060740	prostate gland epithelium morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:0060766	negative regulation of androgen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:109392

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR021064 Estrogen receptor beta, N-terminal

PFAM

PF00104
PF00105
PF12497

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt