InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Galnt7

Summary

InnateDB Protein

IDBP-260530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Galnt7

Protein Name

UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7

Synonyms

AI225872;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105945

InnateDB Gene

IDBG-156288 (Galnt7)

Protein Structure

UniProt Annotation

Function

Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in sublingual gland. Expressed at lower level in stomach, small intestiine and colon. {ECO:0000269PubMed:10488133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.