Version 5.4
Mus musculus Protein: Fgd3
Summary
InnateDB Protein IDBP-261019.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgd3
Protein Name FYVE, RhoGEF and PH domain containing 3
Synonyms 5830461L01Rik; ZFYVE5;
Species Mus musculus
Ensembl Protein ENSMUSP00000105713
InnateDB Gene IDBG-150600 (Fgd3)
Protein Structure
UniProt Annotation
Function Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269PubMed:10721717}.
Subcellular Localization Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in adult brain, spleen, lung and skeletal muscle. Detected in embryos from E7 to E17. {ECO:0000269PubMed:10721717}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0046847 filopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:1353657
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88842
PhosphoSite PhosphoSite-O88842
TrEMBL
UniProt Splice Variant
Entrez Gene 30938
UniGene Mm.291089
RefSeq
MGI ID
MGI Symbol Fgd3
OMIM
CCDS
HPRD
IMGT
EMBL AF017369 AK051395 BC132340 BC137954
GenPept AAC35431 AAI32341 AAI37955 BAC34624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca