InnateDB Protein
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IDBP-261179.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Arc
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Protein Name
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activity regulated cytoskeletal-associated protein
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Synonyms
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Arc3.1; arg3.1; C86064; mArc;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105636
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InnateDB Gene
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IDBG-149967 (Arc)
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Protein Structure
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Function |
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. {ECO:0000250, ECO:0000269PubMed:17088210, ECO:0000269PubMed:17088213}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250UniProtKB:Q63053}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:12493697}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Enriched on the plasma membrane (By similarity). Associated with the sperm tail. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain and testis. {ECO:0000269PubMed:12493697}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88067
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InterPro |
IPR023263
Activity-regulated cytoskeleton-associated protein
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PFAM |
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PRINTS |
PR02027
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WV31
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PhosphoSite |
PhosphoSite-Q9WV31
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11838
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UniGene |
Mm.397271
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RefSeq |
NP_001263613
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MGI ID |
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MGI Symbol |
Arc
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OMIM |
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CCDS |
CCDS37102
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HPRD |
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IMGT |
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EMBL |
AF162777
AF177701
AF254662
AK157822
AK170446
BC023127
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GenPept |
AAD43586
AAG10254
AAH23127
AAK91587
BAE34212
BAE41804
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