InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx39

Summary

InnateDB Protein

IDBP-261589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx39

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39

Synonyms

2610307C23Rik; BAT1; Ddx39a; DDXL; URH49;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105435

InnateDB Gene

IDBG-172499 (Ddx39)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Can translocate to the cytoplasm in the presence of MX1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006406	mRNA export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1915528

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VDW0