InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mast1

Summary

InnateDB Protein

IDBP-261738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mast1

Protein Name

microtubule associated serine/threonine kinase 1

Synonyms

9430008B02Rik; SAST; SAST170;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105363

InnateDB Gene

IDBG-175299 (Mast1)

Protein Structure

UniProt Annotation

Function

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. {ECO:0000269PubMed:10404183, ECO:0000303PubMed:10404183}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10404183}; Peripheral membrane protein {ECO:0000269PubMed:10404183}; Cytoplasmic side {ECO:0000269PubMed:10404183}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10404183}. Note=Colocalizes with syntrophins at the cell membrane.

Disease Associations

Tissue Specificity

Expressed in the vascular endothelium and in proximity to neuronal nuclei throughout the cortex and cerebellum. Also detected in ependymal cells, the choroid plexus, in developing spermatid acrosomes and in both the cell bodies and axonal processes of motor neurons. Observed as punctate clusters in the processes of interneurons and along the cell body periphery. {ECO:0000269PubMed:10404183}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1861901

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001478 PDZ domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain

PFAM

PF00069
PF07714
PF00595
PF13180
PF08926

PRINTS

PR00109

PIRSF

SMART

SM00228
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt