InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: a

Summary

InnateDB Protein

IDBP-261844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

nonagouti

Synonyms

A; As; ASIP; ASP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105319

InnateDB Gene

IDBG-210497 (a)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Epithelial cells of the hair follicles and the epidermis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0031779	melanocortin receptor binding
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0008343	adult feeding behavior
GO:0009755	hormone-mediated signaling pathway
GO:0032402	melanosome transport
GO:0032438	melanosome organization
GO:0040030	regulation of molecular function, epigenetic
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0071514	genetic imprinting