Version 5.4
Mus musculus Protein: Irak4
Summary
InnateDB Protein IDBP-262795.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Irak4
Protein Name interleukin-1 receptor-associated kinase 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104871
InnateDB Gene IDBG-177236 (Irak4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005149 interleukin-1 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001816 cytokine production
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID MGI:2182474
InterPro IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain
IPR017428 Interleukin-1 receptor-associated kinase 4
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00531
PF00069
PF07714
PRINTS PR00109
PIRSF PIRSF038189
SMART SM00005
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3USX5
UniProt Splice Variant
Entrez Gene 266632
UniGene Mm.422858
RefSeq
MGI ID
MGI Symbol Irak4
OMIM
CCDS
HPRD
IMGT
EMBL AC147160 AK139992
GenPept BAE24205

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca