InnateDB Protein
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IDBP-263094.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wwox
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Protein Name
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WW domain-containing oxidoreductase
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Synonyms
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5330426P09Rik; 9030416C10Rik; WOX1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104735
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InnateDB Gene
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IDBG-194458 (Wwox)
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Protein Structure
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Function |
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)- mediated cell death. Required for normal bone development. {ECO:0000250, ECO:0000269PubMed:11058590, ECO:0000269PubMed:19366691}.
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Subcellular Localization |
Cytoplasm. Nucleus. Mitochondrion {ECO:0000250}. Note=Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. In the brain, expressed in cortex, striatum, hippocampus and cerebellum (at protein level). Detected in embryonic skeleton, in cranofacial bones, vertebrae and limb bones. Detected in chondrocytes and osteoblasts. {ECO:0000269PubMed:15026124, ECO:0000269PubMed:17360458, ECO:0000269PubMed:18487609}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
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Biological Process |
GO:0001649
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osteoblast differentiation
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GO:0016055
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Wnt signaling pathway
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GO:0030178
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negative regulation of Wnt signaling pathway
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048705
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skeletal system morphogenesis
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GO:0055114
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oxidation-reduction process
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GO:0071560
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cellular response to transforming growth factor beta stimulus
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GO:0072332
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intrinsic apoptotic signaling pathway by p53 class mediator
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GO:0097191
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extrinsic apoptotic signaling pathway
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GO:2001238
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positive regulation of extrinsic apoptotic signaling pathway
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GO:2001241
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positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
MGI:1931237
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InterPro |
IPR001202
WW domain
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PFAM |
PF00397
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PRINTS |
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PIRSF |
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SMART |
SM00456
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TIGRFAMs |
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Modification |
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SwissProt |
Q91WL8
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PhosphoSite |
PhosphoSite-Q91WL8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80707
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UniGene |
Mm.448693
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RefSeq |
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MGI ID |
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MGI Symbol |
Wwox
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF187014
AH011063
AK018507
AK019911
AK046903
AK078528
BC014716
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GenPept |
AAF31693
AAH14716
AAL03972
BAB31244
BAB31911
BAC32916
BAC37325
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