InnateDB Protein
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IDBP-263141.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2b
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Protein Name
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ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae)
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Synonyms
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2610301N02Rik; E2-14k; HR6B; mHR6B; Rad6b;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104714
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InnateDB Gene
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IDBG-170683 (Ube2b)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
57 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:102944
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63147
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A2RSE4
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UniProt Splice Variant |
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Entrez Gene |
22210
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UniGene |
Mm.469737
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RefSeq |
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MGI ID |
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MGI Symbol |
Ube2b
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OMIM |
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CCDS |
CCDS24664
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HPRD |
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IMGT |
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EMBL |
AK010432
AK011363
AK147785
AK169229
BC132075
BC132077
CH466575
U57690
X96859
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GenPept |
AAC52884
AAI32076
AAI32078
BAB26934
BAB27570
BAE28135
BAE40998
CAA65602
EDL33639
EDL33640
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