Version 5.4
Mus musculus Protein: Th1l
Summary
InnateDB Protein IDBP-263159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Th1l
Protein Name TH1-like homolog (Drosophila)
Synonyms 2410003I03Rik; C77797; Th1; Th1l;
Species Mus musculus
Ensembl Protein ENSMUSP00000104703
InnateDB Gene IDBG-213470 (Th1l)
Protein Structure
UniProt Annotation
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0032021 NELF complex
Protein Structure and Domains
PDB ID MGI:1926424
InterPro IPR006942 TH1 protein
PFAM PF04858
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922L6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 57314
UniGene Mm.271709
RefSeq NP_065605
MGI ID
MGI Symbol Nelfcd
OMIM
CCDS CCDS38358
HPRD
IMGT
EMBL AJ238741 AJ238742 AJ238743 AK010360 AK049418 AL844534 BC006959 BC031747
GenPept AAH06959 AAH31747 BAB26880 BAC33744 CAB65252 CAB65253 CAB65254 CAM26333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca