Version 5.4
Mus musculus Protein: Bhlhe23
Summary
InnateDB Protein IDBP-263603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bhlhe23
Protein Name basic helix-loop-helix family, member e23
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104506
InnateDB Gene IDBG-213911 (Bhlhe23)
Protein Structure
UniProt Annotation
Function May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation. {ECO:0000269PubMed:11863370, ECO:0000269PubMed:15363390}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in brain and retina.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046548 retinal rod cell development
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0048050 post-embryonic eye morphogenesis
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2153710
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGW3
PhosphoSite PhosphoSite-
TrEMBL Q0VEJ8
UniProt Splice Variant
Entrez Gene 140489
UniGene Mm.134062
RefSeq NP_542372
MGI ID
MGI Symbol Bhlhe23
OMIM
CCDS CCDS17187
HPRD
IMGT
EMBL AB053118 AF454760 AK044215 AK051155 BC119208 BC119210 CH466626
GenPept AAI19209 AAI19211 AAL51039 BAC31821 BAC34539 BAC81773 EDL07357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca