Version 5.4
Mus musculus Protein: Cd68
Summary
InnateDB Protein IDBP-264076.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd68
Protein Name CD68 antigen
Synonyms gp110; Lamp4; Scard1;
Species Mus musculus
Ensembl Protein ENSMUSP00000104294
InnateDB Gene IDBG-191443 (Cd68)
Protein Structure
UniProt Annotation
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Subcellular Localization Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.Isoform Short: Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in tissue macrophages and to a lesser extent in dendritic cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:88342
InterPro IPR002000 Lysosome-associated membrane glycoprotein
PFAM PF01299
PRINTS PR00336
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31996
PhosphoSite PhosphoSite-P31996
TrEMBL
UniProt Splice Variant
Entrez Gene 12514
UniGene Mm.15819
RefSeq NP_033983
MGI ID
MGI Symbol Cd68
OMIM
CCDS
HPRD
IMGT
EMBL AB009287 AF022651 AF039399 AF045554 AK002264 AK170443 AL603707 BC021637 DQ167574 X68273
GenPept AAC15685 AAC40056 AAC40151 AAH21637 ABA02181 BAA23738 BAB21975 BAE41801 CAA48334 CAI51942

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca