Version 5.4
Homo sapiens Protein: HBE1
Summary
InnateDB Protein IDBP-26447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBE1
Protein Name hemoglobin, epsilon 1
Synonyms HBE;
Species Homo sapiens
Ensembl Protein ENSP00000369586
InnateDB Gene IDBG-236544 (HBE1)
Protein Structure
UniProt Annotation
Function The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
Subcellular Localization
Disease Associations
Tissue Specificity Red blood cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0031721 hemoglobin alpha binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007596 blood coagulation
GO:0015671 oxygen transport
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005829 cytosol
GO:0005833 hemoglobin complex
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000971 Globin
IPR002335 Myoglobin
IPR002337 Haemoglobin, beta
IPR009050 Globin-like
PFAM PF00042
PRINTS PR00613
PR00814
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02100
PhosphoSite PhosphoSite-P02100
TrEMBL D9YZU7
UniProt Splice Variant
Entrez Gene 3046
UniGene Hs.655195
RefSeq
HUGO HGNC:4830
OMIM 142100
CCDS CCDS7756
HPRD 00788
IMGT
EMBL AC087380 AC104389 BC015537 CH471064 CR541912 GU324924 U01317 V00508
GenPept AAA16330 AAH15537 ADL14495 CAA23766 CAG46710 EAW68802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca