InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mecom

Summary

InnateDB Protein

IDBP-264894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mecom

Protein Name

MDS1 and EVI1 complex locus

Synonyms

D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1; Mds1-Evi1; Prdm3; Znfpr1b1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103905

InnateDB Gene

IDBG-135456 (Mecom)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269PubMed:15889140, ECO:0000269PubMed:18619962, ECO:0000269PubMed:19767769}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:2106070}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0030154	cell differentiation
GO:0043069	negative regulation of programmed cell death
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046329	negative regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0071425	hematopoietic stem cell proliferation