Version 5.4
Mus musculus Protein: Pik3ca
Summary
InnateDB Protein IDBP-264952.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Pik3ca
Protein Name phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
Synonyms 6330412C24Rik; caPI3K; p110; p110alpha;
Species Mus musculus
Ensembl Protein ENSMUSP00000103877
InnateDB Gene IDBG-136530 (Pik3ca)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560 insulin receptor substrate binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0040014 regulation of multicellular organism growth
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID MGI:1206581
InterPro IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR029071 Ubiquitin-related domain
PFAM PF00168
PF00794
PF00454
PF00613
PF00792
PRINTS PR00360
PIRSF
SMART SM00239
SM00144
SM00146
SM00145
SM00142
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YY41
UniProt Splice Variant
Entrez Gene 18706
UniGene Mm.474860
RefSeq
MGI ID
MGI Symbol Pik3ca
OMIM
CCDS
HPRD
IMGT
EMBL AC110034 AC130281 CH466530
GenPept EDL34989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca