Version 5.4
Mus musculus Protein: Stxbp4
Summary
InnateDB Protein IDBP-265744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stxbp4
Protein Name syntaxin binding protein 4
Synonyms 6030470M02Rik; Synip;
Species Mus musculus
Ensembl Protein ENSMUSP00000103507
InnateDB Gene IDBG-208360 (Stxbp4)
Protein Structure
UniProt Annotation
Function Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. {ECO:0000269PubMed:10394363, ECO:0000269PubMed:12855681}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10394363}.
Disease Associations
Tissue Specificity Detected in skeletal muscle, heart, testis, adipocytes and pancreatic islet cells. {ECO:0000269PubMed:10394363, ECO:0000269PubMed:12855681}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006605 protein targeting
GO:0008286 insulin receptor signaling pathway
GO:0015758 glucose transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID MGI:1342296
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WV89
PhosphoSite PhosphoSite-Q9WV89
TrEMBL B1ATH0
UniProt Splice Variant
Entrez Gene 20913
UniGene Mm.473537
RefSeq
MGI ID 1WI4
MGI Symbol Stxbp4
OMIM
CCDS
HPRD
IMGT
EMBL AF152924 AK138499 AL646046 BC032881
GenPept AAD43533 AAH32881 BAE23686 CAI23907 CAI23908 CAI23909 CAI23910 CAI23911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca