InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gngt2

Summary

InnateDB Protein

IDBP-266087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gngt2

Protein Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Synonyms

AV096488;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103340

InnateDB Gene

IDBG-209692 (Gngt2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway

Cellular Component

GO:0005834

heterotrimeric G-protein complex

Protein Structure and Domains

PDB ID

MGI:893584

InterPro

IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain

PFAM

PF00631

PRINTS

PR00321

PIRSF

SMART

SM00224

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61017

PhosphoSite

PhosphoSite-

TrEMBL

A2A614

UniProt Splice Variant

Entrez Gene

14710

UniGene

RefSeq

MGI ID

MGI Symbol

Gngt2

OMIM

CCDS

CCDS25284

HPRD

IMGT

EMBL

AK010554 AL593858 CH466556 U38500

GenPept

AAB01731 BAB27023 CAM15514 EDL15997 EDL15998