InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFNB3

Summary

InnateDB Protein

IDBP-26632.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNB3

Protein Name

ephrin-B3

Synonyms

EFL6; EPLG8; LERK8;

Species

Homo sapiens

Ensembl Protein

ENSP00000226091

InnateDB Gene

IDBG-26628 (EFNB3)

Protein Structure

UniProt Annotation

Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005005	transmembrane-ephrin receptor activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007628	adult walking behavior
GO:0016032	viral process
GO:0016198	axon choice point recognition
GO:0048013	ephrin receptor signaling pathway