InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plxdc1

Summary

InnateDB Protein

IDBP-266398.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxdc1

Protein Name

plexin domain containing 1

Synonyms

2410003I07Rik; AI848450; Tem7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103191

InnateDB Gene

IDBG-210396 (Plxdc1)

Protein Structure

UniProt Annotation

Function

Plays a critical role in endothelial cell capillary morphogenesis. {ECO:0000269PubMed:16202431}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000250}. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain. Highly expressed in Purkinje cells of the cerebellum. {ECO:0000269PubMed:11559528}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0021510	spinal cord development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043235	receptor complex