InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shc1

Summary

InnateDB Protein

IDBP-266715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shc1

Protein Name

src homology 2 domain-containing transforming protein C1

Synonyms

p66; p66shc; Shc; ShcA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103040

InnateDB Gene

IDBG-164495 (Shc1)

Protein Structure

UniProt Annotation

Function

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. {ECO:0000250, ECO:0000269PubMed:12571362, ECO:0000269PubMed:17272725}.

Subcellular Localization

Cytoplasm {ECO:0000250}.Isoform p47Shc: Mitochondrion matrix {ECO:0000250}. Note=Targeting of isoform p47Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization (By similarity). {ECO:0000250}.Isoform p66Shc: Mitochondrion {ECO:0000269PubMed:17272725}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in neural stem cells but absent in mature neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 201 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	201 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0007507	heart development
GO:0016337	single organismal cell-cell adhesion
GO:0031532	actin cytoskeleton reorganization
GO:0040008	regulation of growth