InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Creb3l4

Summary

InnateDB Protein

IDBP-266814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Creb3l4

Protein Name

cAMP responsive element binding protein 3-like 4

Synonyms

1700012K17Rik; 5330432F22Rik; AIBZIP; Atce1; AV040530; AV258827; CREB3; CREB4; JAL; mJAL; TISP40; Tisp40alpha; Tisp40beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102992

InnateDB Gene

IDBG-166231 (Creb3l4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that may play a role in the unfolded protein response of the testis. Proposed to be involved in spermiogenesis. May be involved in regulating the maturation of sperm head nuclei. Alternatively proposed to be a paternally delivered transcription factor that may function in early zygotic gene activation. Increases the binding of CREM isoform Tau with CRE. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange. {ECO:0000269PubMed:16107712, ECO:0000269PubMed:16595651, ECO:0000269PubMed:16925989, ECO:0000269PubMed:16999736}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16925989}; Single-pass type II membrane protein {ECO:0000269PubMed:16925989}. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000269PubMed:16925989}; Single-pass type II membrane protein {ECO:0000269PubMed:16925989}. Note=According to PubMed:16925989 is not observed within nuclei of haploid spermatids at any spermiogenic stage.Processed cyclic AMP-responsive element- binding protein 3-like protein 4: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Disease Associations

Tissue Specificity

Predominantly expressed at high levels in testis with isoform 2 being the predominant isoform. Specifically expressed in postmeiotic spermatids and accumulates in the mid/late stage (at protein level). Ubiquitously expressed at low levels. {ECO:0000269PubMed:11956138, ECO:0000269PubMed:15938716, ECO:0000269PubMed:16107712, ECO:0000269PubMed:16728718, ECO:0000269PubMed:16925989}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0002079	inner acrosomal membrane
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane