InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAH2

Summary

InnateDB Protein

IDBP-26714.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAH2

Protein Name

dynein, axonemal, heavy chain 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373825

InnateDB Gene

IDBG-26706 (DNAH2)

Protein Structure

UniProt Annotation

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. {ECO:0000269PubMed:9256245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0001539	cilium or flagellum-dependent cell motility
GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0008152	metabolic process

Cellular Component

GO:0005858	axonemal dynein complex
GO:0005874	microtubule
GO:0030286	dynein complex

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004273 Dynein heavy chain domain
IPR011704 ATPase, dynein-related, AAA domain
IPR013594 Dynein heavy chain, domain-1
IPR013602 Dynein heavy chain, domain-2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM