InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ngf

Summary

InnateDB Protein

IDBP-267756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ngf

Protein Name

nerve growth factor

Synonyms

Ngfb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102538

InnateDB Gene

IDBG-180362 (Ngf)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005163	nerve growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0006954	inflammatory response
GO:0007422	peripheral nervous system development
GO:0007613	memory
GO:0007623	circadian rhythm
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009314	response to radiation
GO:0009612	response to mechanical stimulus
GO:0010033	response to organic substance
GO:0010193	response to ozone
GO:0010628	positive regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014042	positive regulation of neuron maturation
GO:0014070	response to organic cyclic compound
GO:0019233	sensory perception of pain
GO:0030307	positive regulation of cell growth
GO:0031175	neuron projection development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032496	response to lipopolysaccharide
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045773	positive regulation of axon extension
GO:0046928	regulation of neurotransmitter secretion
GO:0048812	neuron projection morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384	response to glucocorticoid
GO:0051388	positive regulation of nerve growth factor receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0051602	response to electrical stimulus
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000648	positive regulation of stem cell proliferation
GO:2000675	negative regulation of type B pancreatic cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:97321

InterPro

IPR002072 Nerve growth factor-related
IPR020425 Nerve growth factor, beta subunit
IPR020437 Nerve growth factor, beta subunit, mammalian
IPR029034 Cystine-knot cytokine

PFAM

PF00243

PRINTS

PR00268
PR01913
PR01925

PIRSF

SMART

SM00140

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt