Version 5.4
Homo sapiens Protein: ICAM4
Summary
InnateDB Protein IDBP-26865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICAM4
Protein Name intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Synonyms CD242; LW;
Species Homo sapiens
Ensembl Protein ENSP00000342114
InnateDB Gene IDBG-26863 (ICAM4)
Protein Structure
UniProt Annotation
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. {ECO:0000269PubMed:11435317}.
Subcellular Localization Isoform Long: Cell membrane; Single-pass type I membrane protein.Isoform Short: Secreted.
Disease Associations
Tissue Specificity Erythrocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013768 Intercellular adhesion molecule, N-terminal
PFAM PF03921
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14773
PhosphoSite PhosphoSite-
TrEMBL U5U6P8
UniProt Splice Variant
Entrez Gene 3386
UniGene Hs.706750
RefSeq NP_001034221
HUGO HGNC:5347
OMIM 614088
CCDS CCDS32904
HPRD 00198
IMGT
EMBL AC011511 BC000046 BC029364 BT009816 CH471106 DQ011692 KF712272 KF725834 KF725835 KF725837 L27670 L27671 S78852 X93093
GenPept AAA59537 AAA59538 AAB35046 AAH00046 AAH29364 AAP88818 AAY16986 AGZ16506 AGZ17094 AGZ17095 AGZ17097 CAA63646 EAW84089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca