InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmc8

Summary

InnateDB Protein

IDBP-268987.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmc8

Protein Name

transmembrane channel-like gene family 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101941

InnateDB Gene

IDBG-214578 (Tmc8)

Protein Structure

UniProt Annotation

Function

Probable ion channel. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in thymus, lung, prostate, placenta, testis and spleen. {ECO:0000269PubMed:12812529, ECO:0000269PubMed:12906855}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Biological Process

GO:0001558	regulation of cell growth
GO:0006811	ion transport
GO:0032091	negative regulation of protein binding
GO:0032460	negative regulation of protein oligomerization
GO:0055069	zinc ion homeostasis
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome