InnateDB Protein
|
IDBP-269042.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Hivep3
|
Protein Name
|
human immunodeficiency virus type I enhancer binding protein 3
|
Synonyms
|
2900056N03Rik; A130075N07; AI848000; E030045D18Rik; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3; Zas3;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000101914
|
InnateDB Gene
|
IDBG-183408 (Hivep3)
|
Protein Structure
|
|
Function |
Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down- regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269PubMed:10625627, ECO:0000269PubMed:11035930, ECO:0000269PubMed:11804591, ECO:0000269PubMed:12001065, ECO:0000269PubMed:12193271, ECO:0000269PubMed:14530385, ECO:0000269PubMed:14707112, ECO:0000269PubMed:8255760, ECO:0000269PubMed:8812474}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11804591}. Nucleus {ECO:0000269PubMed:11804591}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in macrophages, lymphocytes, brain, thymus, spleen and bone marrow. Expressed in osteoblasts, whole bone and, to a lesser extend, in osteoclasts. {ECO:0000269PubMed:14530385, ECO:0000269PubMed:16728642, ECO:0000269PubMed:8255760, ECO:0000269PubMed:8812474}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
7 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0035914
|
skeletal muscle cell differentiation
|
GO:0045893
|
positive regulation of transcription, DNA-templated
|
|
Cellular Component |
|
PDB ID |
MGI:106589
|
InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
|
PFAM |
PF00096
|
PRINTS |
|
PIRSF |
|
SMART |
SM00355
|
TIGRFAMs |
|
Modification |
|
SwissProt |
A2A884
|
PhosphoSite |
PhosphoSite-A2A884
|
TrEMBL |
Q3UTY2
|
UniProt Splice Variant |
|
Entrez Gene |
16656
|
UniGene |
Mm.401280
|
RefSeq |
NP_034787
|
MGI ID |
|
MGI Symbol |
Hivep3
|
OMIM |
|
CCDS |
CCDS38863
|
HPRD |
|
IMGT |
|
EMBL |
AK138988
AK173200
AL607142
AY454345
L07911
|
GenPept |
AAA40039
AAR88090
BAD32478
BAE23848
CAM27499
|
|
|