InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cant1

Summary

InnateDB Protein

IDBP-269079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cant1

Protein Name

calcium activated nucleotidase 1

Synonyms

5830420C20Rik; Apy1h; D11Bwg0554e; Entpd8; SCAN-1; Shapy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101896

InnateDB Gene

IDBG-214641 (Cant1)

Protein Structure

UniProt Annotation

Function

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (By similarity). Involved in proteoglycan synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Processed form: Secreted. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004382	guanosine-diphosphatase activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0016462	pyrophosphatase activity
GO:0045134	uridine-diphosphatase activity

Biological Process

GO:0007165	signal transduction
GO:0009191	ribonucleoside diphosphate catabolic process
GO:0030166	proteoglycan biosynthetic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane