InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gaa

Summary

InnateDB Protein

IDBP-269143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gaa

Protein Name

glucosidase, alpha, acid

Synonyms

E430018M07Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101866

InnateDB Gene

IDBG-214686 (Gaa)

Protein Structure

UniProt Annotation

Function

Essential for the degradation of glygogen to glucose in lysosomes.

Subcellular Localization

Lysosome. Lysosome membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558	alpha-glucosidase activity
GO:0030246	carbohydrate binding
GO:0032450	maltose alpha-glucosidase activity

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002086	diaphragm contraction
GO:0003007	heart morphogenesis
GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005980	glycogen catabolic process
GO:0006941	striated muscle contraction
GO:0007040	lysosome organization
GO:0007626	locomotory behavior
GO:0009888	tissue development
GO:0043181	vacuolar sequestering
GO:0043587	tongue morphogenesis
GO:0046716	muscle cell cellular homeostasis
GO:0050884	neuromuscular process controlling posture
GO:0050885	neuromuscular process controlling balance
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95609

InterPro

IPR000322 Glycoside hydrolase, family 31
IPR000519 P-type trefoil
IPR011013 Galactose mutarotase-like domain
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF01055
PF00088

PRINTS

PIRSF

SMART

SM00018

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70699