InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tial1

Summary

InnateDB Protein

IDBP-269218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tial1

Protein Name

Tia1 cytotoxic granule-associated RNA binding protein-like 1

Synonyms

5330433G13Rik; AL033329; mTIAR; TIAR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101833

InnateDB Gene

IDBG-210657 (Tial1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19861488}. Nucleus {ECO:0000269PubMed:19861488}. Cytoplasmic granule {ECO:0000269PubMed:19861488}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules.

Disease Associations

Tissue Specificity

Expressed both in primordial germ cells (PGCs) and in neighboring somatic cells. {ECO:0000269PubMed:19861488}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0044822	poly(A) RNA binding