InnateDB Protein
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IDBP-269362.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ssx2ip
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Protein Name
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synovial sarcoma, X breakpoint 2 interacting protein
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Synonyms
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Adip; AU014939; AU042321;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101757
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InnateDB Gene
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IDBG-199101 (Ssx2ip)
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Protein Structure
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Function |
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling. {ECO:0000250, ECO:0000269PubMed:12446711, ECO:0000269PubMed:22027834}.
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Subcellular Localization |
Cell junction, adherens junction {ECO:0000269PubMed:12446711}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Note=Not found at cell-matrix AJs.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:12446711}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2139150
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InterPro |
IPR021622
Afadin/alpha-actinin-binding
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PFAM |
PF11559
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VC66
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PhosphoSite |
PhosphoSite-Q8VC66
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TrEMBL |
D3Z6T5
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UniProt Splice Variant |
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Entrez Gene |
99167
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UniGene |
Mm.488685
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RefSeq |
NP_001240698
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MGI ID |
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MGI Symbol |
Ssx2ip
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OMIM |
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CCDS |
CCDS57260
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HPRD |
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IMGT |
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EMBL |
AC124987
AF532969
AK031356
AK043865
AK049080
BC021749
BC031527
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GenPept |
AAH21749
AAH31527
AAO15015
BAC27363
BAC31684
BAC33536
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