InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam8

Summary

InnateDB Protein

IDBP-269520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam8

Protein Name

a disintegrin and metallopeptidase domain 8

Synonyms

CD156; CD156a; E430039A18Rik; MS2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101684

InnateDB Gene

IDBG-211612 (Adam8)

Protein Structure

UniProt Annotation

Function

Possible involvement in extravasation of leukocytes.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002675	positive regulation of acute inflammatory response
GO:0002693	positive regulation of cellular extravasation
GO:0006508	proteolysis
GO:0006954	inflammatory response
GO:0007160	cell-matrix adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0022407	regulation of cell-cell adhesion
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0035419	activation of MAPK activity involved in innate immune response
GO:0043524	negative regulation of neuron apoptotic process
GO:0043534	blood vessel endothelial cell migration
GO:0045670	regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045785	positive regulation of cell adhesion
GO:0048247	lymphocyte chemotaxis
GO:0048729	tissue morphogenesis
GO:0050729	positive regulation of inflammatory response
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0061025	membrane fusion
GO:0070245	positive regulation of thymocyte apoptotic process
GO:0071456	cellular response to hypoxia
GO:0072675	osteoclast fusion
GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391	positive regulation of neutrophil extravasation
GO:2000399	negative regulation of thymocyte aggregation
GO:2000406	positive regulation of T cell migration
GO:2000415	positive regulation of fibronectin-dependent thymocyte migration
GO:2000418	positive regulation of eosinophil migration

Cellular Component

GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0032010	phagolysosome
GO:0032127	dense core granule membrane
GO:0042581	specific granule
GO:0070820	tertiary granule
GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133	alpha9-beta1 integrin-ADAM8 complex

Protein Structure and Domains

PDB ID

MGI:107825

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt