InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirt3

Summary

InnateDB Protein

IDBP-269578.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt3

Protein Name

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

Synonyms

2310003L23Rik; AI848213; Sir2l3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101663

InnateDB Gene

IDBG-211875 (Sirt3)

Protein Structure

UniProt Annotation

Function

NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269PubMed:16790548, ECO:0000269PubMed:17923681, ECO:0000269PubMed:18794531, ECO:0000269PubMed:21172655, ECO:0000269PubMed:21858060, ECO:0000269PubMed:23835326, ECO:0000269PubMed:24252090}.

Subcellular Localization

Isoform L: Mitochondrion matrix.Isoform S: Cytoplasm.

Disease Associations

Tissue Specificity

Strongly expressed in liver and kidney. Weakly expressed in lung. {ECO:0000269PubMed:11056054}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051287	NAD binding
GO:0070403	NAD+ binding