Version 5.4
Mus musculus Protein: Catsper4
Summary
InnateDB Protein IDBP-269937.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Catsper4
Protein Name cation channel, sperm associated 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000101504
InnateDB Gene IDBG-195943 (Catsper4)
Protein Structure
UniProt Annotation
Function Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone. {ECO:0000269PubMed:17227845, ECO:0000269PubMed:17344468}.
Subcellular Localization Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}; Multi- pass membrane protein {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}. Note=Specifically located in the principal piece of sperm tail.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005227 calcium activated cation channel activity
Biological Process
GO:0006812 cation transport
GO:0030317 sperm motility
Cellular Component
GO:0036128 CatSper complex
Protein Structure and Domains
PDB ID MGI:3043288
InterPro IPR016185 Pre-ATP-grasp domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Z4YKD2
UniProt Splice Variant
Entrez Gene 329954
UniGene Mm.79072
RefSeq
MGI ID
MGI Symbol Catsper4
OMIM
CCDS
HPRD
IMGT
EMBL AL627314
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca