Homo sapiens Protein: WBP4
Summary
InnateDB Protein IDBP-27006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WBP4
Protein Name WW domain binding protein 4 (formin binding protein 21)
Synonyms FBP21;
Species Homo sapiens
Ensembl Protein ENSP00000368801
InnateDB Gene IDBG-27004 (WBP4)
Protein Structure
UniProt Annotation
Function Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. {ECO:0000269PubMed:19592703, ECO:0000269PubMed:9724750}.
Subcellular Localization Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00130, ECO:0000269PubMed:19592703, ECO:0000269PubMed:9724750}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
Experimentally validated
Total 87 [view]
Protein-Protein 85 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0070064 proline-rich region binding
Biological Process
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005886 plasma membrane
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000690 Zinc finger, C2H2-type matrin
IPR001202 WW domain
IPR003604 Zinc finger, U1-type
IPR013085 Zinc finger, U1-C type
PFAM PF00397
PF06220
PRINTS
PIRSF
SMART SM00456
SM00451
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75554
PhosphoSite PhosphoSite-O75554
TrEMBL B7Z4M2
UniProt Splice Variant
Entrez Gene 11193
UniGene Hs.595899
RefSeq NP_009118
HUGO HGNC:12739
OMIM 604981
CCDS CCDS9375
HPRD 16086
IMGT
EMBL AF071185 AK297536 AL157877 BC104879 BC108310
GenPept AAC34811 AAI04880 AAI08311 BAH12608 CAI13223