Version 5.4
Mus musculus Protein: Pla2g2d
Summary
InnateDB Protein IDBP-270085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g2d
Protein Name phospholipase A2, group IID
Synonyms mGIID; Splash;
Species Mus musculus
Ensembl Protein ENSMUSP00000101432
InnateDB Gene IDBG-199977 (Pla2g2d)
Protein Structure
UniProt Annotation
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Subcellular Localization Isoform 1: Secreted {ECO:0000305}.Isoform 2: Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in several tissues including pancreas, spleen, thymus, skin, lung, and ovary.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1341796
InterPro IPR001211 Phospholipase A2
IPR016090 Phospholipase A2 domain
PFAM PF05826
PF00068
PRINTS PR00389
PIRSF
SMART SM00085
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVF6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 18782
UniGene Mm.71913
RefSeq XP_006538720
MGI ID
MGI Symbol Pla2g2d
OMIM
CCDS
HPRD
IMGT
EMBL AF112983 AF124374 AF169407 AF169408 AF188624 AK004232 AK018005
GenPept AAD42773 AAD51391 AAF09019 AAF42987 AAF42988 BAB31033 BAE43166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca