InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr6

Summary

InnateDB Protein

IDBP-270094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr6

Protein Name

5-hydroxytryptamine (serotonin) receptor 6

Synonyms

5-HT6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101428

InnateDB Gene

IDBG-200185 (Htr6)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210	serotonin receptor signaling pathway
GO:0007420	brain development
GO:0007612	learning
GO:0014050	negative regulation of glutamate secretion
GO:0014053	negative regulation of gamma-aminobutyric acid secretion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014058	negative regulation of acetylcholine secretion, neurotransmission
GO:0032355	response to estradiol
GO:0033603	positive regulation of dopamine secretion
GO:0042493	response to drug
GO:0060291	long-term synaptic potentiation